TB-500
The actin-regulating repair peptide with real early human trials
CAS 885340-08-9$120.00
TB-500
CAS 885340-08-9$120.00
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A synthetic fragment of Thymosin Beta-4 studied for muscle, tendon, and tissue-repair research.
- Ships fast from the US
- Batch number on every vial
- ≥99% HPLC purity target
Before ordering
- For laboratory research use only — not for human or veterinary use.
- Every vial carries a batch number (see Batch Information below).
- Read the Shipping Policy and Refund Policy before ordering.
Research Overview
The actin-regulating repair peptide with real early human trials
TB-500 is the research-market name for synthetic thymosin beta-4 — a naturally occurring 43-amino-acid protein present in nearly all human cells — or its active fragment. Tβ4 regulates actin, the protein cells use to build structure and move, which is why it appears in wound-healing, cardiac, and corneal repair research. Unusually for this space, pharmaceutical versions of Tβ4 have reached early human trials.
Dermal wound healing
Early human trialsFoundational animal work showed topical and injected Tβ4 accelerated wound closure and re-epithelialization. Pharmaceutical Tβ4 subsequently entered Phase 2 human trials for chronic wounds such as pressure and venous stasis ulcers.
Cardiac repair
Preclinical (cell & animal)A landmark Nature study reported that Tβ4 promoted heart-cell migration and survival after experimental myocardial infarction in mice — among the most-cited findings in the entire Tβ4 literature.
Corneal & eye repair
Early human trialsTβ4 eye drops (developed as RGN-259) have been studied in human trials for dry eye disease and neurotrophic keratopathy — the most clinically advanced application of the peptide.
Mechanism: actin regulation
Preclinical (cell & animal)Tβ4 is the body's main actin-sequestering peptide; by binding actin monomers it influences how cells move, divide, and rebuild damaged tissue. This well-characterized mechanism is what separates Tβ4 from peptides whose targets remain speculative.
Human trial data comes from pharmaceutical-grade Tβ4 programs (e.g., RGN-259 eye drops) — not from the gray-market vials sold as 'TB-500.' Results don't automatically transfer.
Technical Specifications
- CAS Number
- 885340-08-9
- Formula
- C212H350N56O78S
- Molecular Weight
- 4963.4 g/mol
- Sequence
- Ac-SDKPDMAEIEKFDKSKLKKTETQEKNPLPSKETIEQEKQAGES (Thymosin β4)
- Purity Target
- ≥99% (HPLC)
- Appearance
- White lyophilized powder
- Vial Size
- 20 mg
- Solubility
- Soluble in bacteriostatic water and sterile water.
- Storage
- Lyophilized: store at -20 C, protected from light. Reconstituted: 2-8 C, use within 28 days.
- Handling
- For laboratory research use only. Handle aseptically and avoid repeated freeze-thaw cycles.
Why RGP
We're deliberately not the cheapest vial on the market. Every batch is manufactured to a ≥99% HPLC purity target, batch-tracked from manufacture to your bench, and shipped fast from the US with full specifications on record. Independent third-party testing is underway — results will be published here as they come in.
