Pinealon
The Khavinson tripeptide suddenly at the center of the sleep-and-longevity conversation
CAS 175175-23-2$59.00
Pinealon
CAS 175175-23-2$59.00
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Pinealon (EDR peptide, Glu-Asp-Arg) is a synthetic tripeptide from the Khavinson bioregulator family, studied in neuroprotection, brain-aging, and circadian-biology research. Published work in neuronal cell models reports reduced reactive-oxygen-species accumulation and improved cell viability under oxidative stress.
Supplied as a 20 mg lyophilized vial. For laboratory research use only — not for human consumption.
- Ships fast from the US
- Batch number on every vial
- ≥99% HPLC purity target
Before ordering
- For laboratory research use only — not for human or veterinary use.
- Every vial carries a batch number (see Batch Information below).
- Read the Shipping Policy and Refund Policy before ordering.
Research Overview
The Khavinson tripeptide suddenly at the center of the sleep-and-longevity conversation
Pinealon is a synthetic three-amino-acid peptide (Glu-Asp-Arg, 'EDR') from the family of short 'peptide bioregulators' developed by Vladimir Khavinson's group at the St. Petersburg Institute of Bioregulation and Gerontology. Designed with the pineal gland and brain aging in mind, it spent decades in relative obscurity — until it abruptly became one of the most-searched peptides of 2026.
Neuroprotection under oxidative stress
Preclinical (cell & animal)The best-documented Pinealon finding: in neuronal cell models, Pinealon dose-dependently limited reactive-oxygen-species accumulation and reduced cell death under oxidative stress, while supporting proliferative activity.
Brain-aging & Alzheimer's models
Preclinical (cell & animal)In an in vitro Alzheimer's-model preparation, EDR and related short peptides restored dendritic spine density; follow-on work reported protective effects in aged, fibroblast-derived induced neurons.
Proposed epigenetic mechanism
Preclinical (cell & animal)Khavinson's group hypothesizes that short peptides like EDR penetrate cells and interact directly with DNA to modulate gene expression and protein synthesis — a provocative mechanism explored in the context of Alzheimer's pathogenesis, but not yet independently confirmed.
Sleep & circadian biology
Preclinical (cell & animal)Pinealon is named for the pineal gland, the brain's melatonin factory, and sits within a research program on pineal aging. Direct evidence that Pinealon improves human sleep, however, is currently anecdote — including the high-profile anecdote that made it famous. It is the single biggest open question about this compound.
Nearly the entire Pinealon literature comes from one research group (Khavinson and collaborators), largely in Russian journals. Independent replication is scarce.
Technical Specifications
- CAS Number
- 175175-23-2
- Formula
- C15H26N6O8
- Molecular Weight
- 418.4 g/mol
- Sequence
- Glu-Asp-Arg
- Purity Target
- ≥99% (HPLC)
- Appearance
- White lyophilized powder
- Vial Size
- 20 mg
- Solubility
- Soluble in bacteriostatic water and sterile water.
- Storage
- Lyophilized: store at -20 C, protected from light. Reconstituted: 2-8 C, use within 28 days.
- Handling
- For laboratory research use only. Handle aseptically and avoid repeated freeze-thaw cycles.
Why RGP
We're deliberately not the cheapest vial on the market. Every batch is manufactured to a ≥99% HPLC purity target, batch-tracked from manufacture to your bench, and shipped fast from the US with full specifications on record. Independent third-party testing is underway — results will be published here as they come in.
